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Vaccine development

 
 
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Vaccine development

Infectious veterinary diseases are of significant, economic importance to Australian Primary Industry because of their deleterious effect on productivity.
 
The ARC Centre of Excellence in Structural & Functional Microbial Genomics is attempting to make significant savings to primary industry, and concomitant benefits for Australian producers and consumers, by developing innovative methods for the control of microbial infections in various animals through the development of novel veterinary vaccines.
 
Using a high-throughput screening approach the Centre is identifying potential vaccine candidates or proteins, selected from input from data sets generated by bioinformatics analysis of genome sequence, microarray and proteomic analysis and genetic studies. These proteins are overexpressed and purified for use in immunisation experiments in animals that determine their immunogenicity and protective efficacy.
 
Key diseases of interest include:
 
Fowl cholera;
Ovine footrot;
Avian necrotic enteritis;
Campylobacteriosis;
Leptospirosis;
Swine dysentery; and
Haemonchus contortus.
 
This approach to vaccine development, known as reverse vaccinology or the genomic approach, has wide applicability to the development of human therapeutics, medical devices, diagnostics, biomarker and other products as well as the advancement of fundamental research. It is made possible by the Centre’s High-throughput Microbial Pipeline - a facility made up of a series of integrated core technologies in proteomics, protein production and X-ray crystallography
 
For further information about the Centre’s vaccine development projects in fowl cholera, leptospirosis or swine dysentery, please contact Centre Research Director Professor Ben Adler.
 
For further information about the Centre’s vaccine development projects in ovine footrot, avian necrotic enteritis or campylobacter infection, please contact Centre Chief Investigator Professor Julian Rood.
 
For further information about the Centre’s vaccine development projects in Haemonchus contortus, please contact Centre Chief Investigator Professor Els Meeusen.
 
Australian Research Council
Monash University
Victorian Government
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