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Innate Immunity

 
  Antimicrobial targets

Bacterial Pathogenesis

Bioinformatics

Host pathogen interactions

Innate Immunity

Proteomics

Structural & functional biology

Vaccine development

While adaptive mammalian immunity is reliant upon the generation of highly diverse cytotoxic T cell receptors, innate immunity depends on an array of host receptors recognising invariant factors present in pathogens. Discovering the basis of these innate responses that modulate host-pathogen interactions will contribute greatly to reduction of bacterial infections.
 
The ARC Centre of Excellence in Structural & Functional Microbial Genomics has several projects elucidating the mechanisms of immunological aspects of mammalian host-pathogen interactions, including:
 
Phospoinositide signalling and phagosome maturation;
Toll-like receptors (TLRs) signalling during infection; and
Structural aspects of Type I interferons (IRNs) and their receptors complexes.
 
For further information about the project on phosphoinositide signalling and phagosome maturation, please contact Centre Chief Investigator Professor Ross Coppel.
 
For further information about the project on Toll-like receptor (TLR) signalling during infection, please contact Centre Chief Investigator Professor Paul Hertzog.
 
For further information about the project on Structural aspects of type I interferon (IFNs) and receptor complexes, please contact Centre Chief Investigator Professor Paul Herzog.
 
Australian Research Council
Monash University
Victorian Government
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