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Host pathogen interactions

 
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Host pathogen interactions

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Elucidating key host-pathogens interactions at the molecular and cellular level provides understanding of how microbes evolve and cause disease.
 
The ARC Centre of Excellence in Structural & Functional Microbial Genomics is utilising its extensive molecular genetics expertise in identifying and characterising the virulence factors of the following microbes:
 
Clostridium perfringens, the causative agent of avian necrotic enteritis;
Mycobacterium spp., the causative agent of several chronic animal, fish and human infections and;
Burkholderia pseudomallei, the causative agent of melioidosis, a serious, fatal infection of livestock and humans in tropical areas.
 
In particular, the Centre focuses on microbial components involved in the primary interaction of the microbe with the host, for example, initial adhesion at host epithelial cell surfaces as well as how bacterial pathogens interact with host innate immunity. Fluorescence labelling and other mammalian cell biology techniques are used to analyse the host response to infection.
 
For further information about the project on host-pathogen interactions in avian necrotic enteritis please contact Centre Chief Investigator Professor Julian Rood.
 
For further information about the project on mechanisms in host-pathogen interactions of Mycobacterium spp. please contact Centre Chief Investigator Professor Ross Coppel or Centre Chief Investigator Professor Phillip Nagley.
 
For further information about the project on host-pathogen interactions involving Burkholderia pseudomallei please contact Centre Chief Investigator and Deputy-Director Professor Rod Devenish or Centre Research Director Professor Ben Adler.
 
Australian Research Council
Monash University
Victorian Government
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