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Bacterial Pathogenesis

 
  Antimicrobial targets

Bacterial Pathogenesis

Bioinformatics

Host pathogen interactions

Innate Immunity

Proteomics

Structural & functional biology

Vaccine development

The identification and characterisation of key microbial virulence factors enables the elucidation of the molecular basis for microbial pathogenesis and advances our understanding of how microorganisms cause disease.
 
The ARC Centre of Excellence in Structural & Functional Microbial Genomics has several projects elucidating the mechanism of the pathogenesis of the following diseases:
 
Pasteurellosis
Ovine footrot
Avian necrotic enteritis
Melioidosis
 
Genes that encode putative virulence factors are selected based on in vivo microarray transcriptional profiling data, bioinformatics and proteomic analysis. Targeted genes are insertionally inactivated and the resultant mutants are assessed for virulence using both in vitro cell adhesion and invasion and animal disease models. Where gene inactivation results in attenuation of virulence, the virulence factor is fully characterised structurally and biochemically.
 
For further information about the projects on mechanisms of pathogenesis of pasteurellosis and meliodosis, please contact Centre Research Director Professor Ben Adler.
 
For further information on the projects on mechanisms of pathogenesis of ovine footrot and avian necrotic enteritis, please contact Centre Chief Investigator Professor Julian Rood.
 
Australian Research Council
Monash University
Victorian Government
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