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Antimicrobial targets

 
  Antimicrobial targets

Bacterial Pathogenesis

Bioinformatics

Host pathogen interactions

Innate Immunity

Proteomics

Structural & functional biology

Vaccine development

The identification of potential targets for the design of novel and specific antimicrobial drugs addresses the problem of increasing animal and human resistance to existing antibiotics or antimicrobial agents.
 
The ARC Centre of Excellence in Structural & Functional Microbial Genomics has several antimicrobial target projects focusing on the identification of specific processes important to pathogenesis involving:
 
Mycobacterium spp., the causative agent of several chronic animal, fish and human infections;
Escherichia coli;
Legionella and;
Leptospira.
 
Using the principles of rational drug design and the Centre’s high-throughput microbial pipeline, candidate proteins are identified using bioinformatics and genomics assays. Further studies using in vitro mutagenesis and domain swapping coupled with functional assays, are defining precise protein regions that are important for pathogen function.
 
For further information about the projects on Leptospira, Legionella or E. coli drug targets, please contact Centre Chief Investigator Professor Jamie Rossjohn.
 
For further information about the project on Mycobacteruim spp. drug targets, please contact Centre Chief Investigator Professor Jamie Rossjohn or Centre Chief Investigator Professor Ross Coppel.
 
Australian Research Council
Monash University
Victorian Government
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